The only religion spread by those Nations was their own form of Christianity, I wasn't implying it was their plan to use smallpox, being used to distribute should have meant some reprisal, their were none.
" In a section on Tribes of the Columbia River region of the Pacific Northwest, James Mooney (anthropologist from the Smithsonian Institution) wrote: "In 1847 the small pox, before unknown among them, carried off a large part of the tribe. The Cayuse, believing that the missionaries were the cause of it, attacked the mission on November 29, 1847, killed Dr. Whitman [a Presbyterian missionary] and thirteen others, and destroyed the mission. As a matter of fact, there seems little question that the infection was brought into the country in supplies intended for the use of the mission or of emigrants temporarily stopping there."
This was originally published in 1896 by the Government Printing Office, Washington, D.C., as an accompanying paper to the _Fourteenth Annual Report (Part 2) of the Bureau of Ethnology of the Smithsonian Institution, 1892-93, By J.W. Powell, Director_. "
It was the RCC in Central/South America take a quick look at Canada and Haiti as to how benign they were.