I haven't personally but someone near and dear to us clearly has been and we watched it happen, helplessly, in real time.
Your demanding questioning is getting too close to some important personal details, so my answer will not be more specific. You do whatever you thing you want to do to yourself.Please don't preach, though that noxious substances are safe for everyone. None of them are and neither is this one.
There is nowhere near enough information available yet to come to that conclusion. We'll see what it's like when a quarter of he population wanders about, stoned off of their heads everyday.