Do you know where your Y chromosome has been?

Dexter Sinister

Unspecified Specialist
Oct 1, 2004
10,168
539
113
Regina, SK
Discover your deep ancestry!

I recently got back the results of an analysis of my Y chromosome from National Geographic's Genographic Project. The project is tracing human migration out of Africa by means of genetic analysis, looking for markers (i.e. small neutral mutations) in mitochondrial DNA for female lineages and on the Y chromosome for male lineages. Humanity emerged in central Africa about 200,000 years ago, and the evidence suggests there were two major migrations into the rest of the world, about 60,000 and 50,000 years ago. Those would have been controlled by climate changes, mainly the advance and retreat of glaciers and concommittant effects like the spread of grasslands and deserts and so on, and our hunter-gatherer ancestors following the herds of animals. The database is good enough that it's known approximately when and where certain mutations first appeared, so the presence of them in your DNA indicates where your ancestors have been, and when. I got this neat little map (attached below) of the path of my Y chromosome over the last 50,000 years, and a 10-page report describing the details. The red line on the map is where my male ancestors went, the blue lines splitting off from it are where other populations separated from them. The labels on the map, like M168, M9, and so on, are the names of the markers used to trace it.

Some highlights: M168 is the only lineage that survives outside of Africa. That mutation appeared about 50,000 years ago in the area of Africa's Great Rift Valley; every non-African man has that marker. M45 appeared about 35,000 years ago on the steppes of central Asia, and the blue line arcing away to the northeast from it appears to be the population that made it across the Bering Strait and into North America. Almost every North American aboriginal man has the M45 marker. M173 appeared about 30,000 years ago, and the arrival of those people in Europe coincides with the demise of the Neanderthals and the creation of what archeologists call the Aurignacian culture. These are the Cro-magnons. Advancing glaciers pushed them south into Spain and Italy 20,000 years ago, and they moved back north around 12,000 years ago as the ice retreated. The map doesn't show all the details of the 10-page report of course. It concludes with my male ancestors being in what are now the Irish counties of Clare, Limerick, and Tipperary at the end of the last ice age.

Anybody can get this done and I encourage everyone to do so, I think this is a fascinating and useful science project. You can order the DNA test kit online, it's about $100 U.S., you send in a couple of cheek scrapings and 8-10 weeks later you can logon to the National Geographic's web site with a code they give you in the kit and get your results. Find out all about it here: https://genographic.nationalgeographic.com/genographic/index.html
 
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Tonington

Hall of Fame Member
Oct 27, 2006
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I've been wanting to do this as well. Get Niflmir to go for the one that I don't, and we'd know both ancestral lineage movements. Funny enough, we start a four week lab in one of my classes today, analysing our own DNA. Looking for some specific markers, like those crime labs would look for. :D
 

Dexter Sinister

Unspecified Specialist
Oct 1, 2004
10,168
539
113
Regina, SK
I think it'd make a great Christmas or birthday gift for someone close to you. That's how I got mine, a birthday gift from one of my sisters. She had the female line of the family traced by giving a kit to one of her daughters for Christmas a few years ago. Now we know our female ancestors left Africa in the first wave and went west from the Middle East along the north shore of the Mediterranean then around the Atlantic coast of Spain, Portugal, and France, ending up in what became Scotland. Our male ancestors were part of the second wave and went east from the Middle East, skirting the northern edges of the Himalayas, then north across the steppes and back west into Europe, ending up in Ireland. We're related by direct descent to populations still in the Middle East, Uzbekistan, Lombardy, Portugal, Normandy, Ireland, and Scotland, and 20th or something like that cousins with everybody in India and the aboriginals in North America.

I think it's cool to know stuff like this, not least because it's among the things that unite us all rather than divide us.
 

AnnaG

Hall of Fame Member
Jul 5, 2009
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Sounds like a heck of a good idea. I thought DNA testing was a lot more expensive than that.
 

petros

The Central Scrutinizer
Nov 21, 2008
117,279
14,263
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Low Earth Orbit
If you ever need a GSM or X-ray Refrac done let me know.

To test the THC in your weed please be sure to send at least 2 oz.
 

AnnaG

Hall of Fame Member
Jul 5, 2009
17,507
117
63
Do you know where your Y chromosome has been?

He was working, then showered and now he's loading the dishwasher. lol (I cooked.)
 

Kreskin

Doctor of Thinkology
Feb 23, 2006
21,155
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Anyone have concerns about this information getting in the wrong hands?

During the first half of the decade I participated in genetic research through UBC. One of the growing concerns at that time was genetic information getting in the hands of life insurance companies. Or, if genetic testing was already done would they insist on the disclosure, just like any other medical record?

Food for thought.
 

AnnaG

Hall of Fame Member
Jul 5, 2009
17,507
117
63
Anyone have concerns about this information getting in the wrong hands?

During the first half of the decade I participated in genetic research through UBC. One of the growing concerns at that time was genetic information getting in the hands of life insurance companies. Or, if genetic testing was already done would they insist on the disclosure, just like any other medical record?

Food for thought.
Good point. A friend of ours is a lawyer that among other things, fights for claimants against ICBC, and he mentioned one time that ICBC goes overboard in requesting medical info about people. Like stuff going back into your childhood and things of a nature that have zilch to do with a car crash. I can imagine that health insurance and death insurance companies would be even more interested in one's genetics.
 

Kreskin

Doctor of Thinkology
Feb 23, 2006
21,155
149
63
Our involvement was as infertility patients, where infertility was caused by genetics. As a result, even my daughter was well documented genetically before she was born. This science moves quickly. In 10 or 20 years, if they can identify previously unknown health risk factors from the information already in her file will that mean it will be used against her? Will disability insurers say she had a pre-existing medical condition? Or even simpler, would they deny a claim because she didn't disclose pre-birth genetic records for their examination during the application process?

I'm obviously going beyond the scope of this thread, and in all likelihood this project wouldn't be a concern. But as time goes on and the ability to send DNA around for analysis gets easier, cheaper and mainstream, it will be important to know what is potentially at stake.
 

Dexter Sinister

Unspecified Specialist
Oct 1, 2004
10,168
539
113
Regina, SK
Yeah, I thought about some of that stuff too. Will life insurance companies want your DNA profile before issuing a policy, and will they reject your application if you have DNA markers associated with early death from various causes? An ugly question. This particular project looked only at my Y chromosome, and the whole process was anonymous. The only link between the analysis and me is the logon code that was in the kit, and the only person who knows that the code identifies me, is me. I provided no name or address. And I think the samples are destroyed by the analytical process anyway. They could I suppose trace me by the IP address they saw when I logged on, but I'm behind a hardware and a software firewall, all they could discover was my ISP, and the IP address is handed out by a DHCP server, it's not constant.
 

Tonington

Hall of Fame Member
Oct 27, 2006
15,441
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It's my understanding that tracing lineage and family markers is for the most part done using the so-called junk DNA. There are specific markers that are part of the profile, but in a lot of cases they don't actually mean anything. The junk DNA that we don't really know what it codes for, is incredibly hereditary.

I think if the insurance companies try to go the DNA route, there would be some difficulty on their part denying claims. I think they could probably increase premiums, but to deny claims would be hard to back up. Many diseases are influenced by genetics, but not necessarily caused. The standard analogy is genetics loads the gun, and the environment pulls the trigger.
 

Trex

Electoral Member
Apr 4, 2007
917
31
28
Hither and yon
Discover your deep ancestry!

I recently got back the results of an analysis of my Y chromosome from National Geographic's Genographic Project. The project is tracing human migration out of Africa by means of genetic analysis, looking for markers (i.e. small neutral mutations) in mitochondrial DNA for female lineages and on the Y chromosome for male lineages. Humanity emerged in central Africa about 200,000 years ago, and the evidence suggests there were two major migrations into the rest of the world, about 60,000 and 50,000 years ago. Those would have been controlled by climate changes, mainly the advance and retreat of glaciers and concommittant effects like the spread of grasslands and deserts and so on, and our hunter-gatherer ancestors following the herds of animals. The database is good enough that it's known approximately when and where certain mutations first appeared, so the presence of them in your DNA indicates where your ancestors have been, and when. I got this neat little map (attached below) of the path of my Y chromosome over the last 50,000 years, and a 10-page report describing the details. The red line on the map is where my male ancestors went, the blue lines splitting off from it are where other populations separated from them. The labels on the map, like M168, M9, and so on, are the names of the markers used to trace it.

Some highlights: M168 is the only lineage that survives outside of Africa. That mutation appeared about 50,000 years ago in the area of Africa's Great Rift Valley; every non-African man has that marker. M45 appeared about 35,000 years ago on the steppes of central Asia, and the blue line arcing away to the northeast from it appears to be the population that made it across the Bering Strait and into North America. Almost every North American aboriginal man has the M45 marker. M173 appeared about 30,000 years ago, and the arrival of those people in Europe coincides with the demise of the Neanderthals and the creation of what archeologists call the Aurignacian culture. These are the Cro-magnons. Advancing glaciers pushed them south into Spain and Italy 20,000 years ago, and they moved back north around 12,000 years ago as the ice retreated. The map doesn't show all the details of the 10-page report of course. It concludes with my male ancestors being in what are now the Irish counties of Clare, Limerick, and Tipperary at the end of the last ice age.

Anybody can get this done and I encourage everyone to do so, I think this is a fascinating and useful science project. You can order the DNA test kit online, it's about $100 U.S., you send in a couple of cheek scrapings and 8-10 weeks later you can logon to the National Geographic's web site with a code they give you in the kit and get your results. Find out all about it here: https://genographic.nationalgeographic.com/genographic/index.html

I did the Genome Project deed well over a year and half ago.
Interesting stuff.
It's amazing what you can find out with a q-tip.

I then pitched in for a secondary analysis on the female side.
I find it all very intriguing.
I now get weekly emails about different folks who are 20 or 30 generations removed from me but somehow are my distant relatives.

Trex