COVID-19 'Pandemic'
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Scientists identify new gene differences in severe COVID patients
Author of the article:Reuters
Reuters
Manas Mishra
Publishing date:Mar 07, 2022 • 15 hours ago • 1 minute read • 8 Comments
COVID-19 vaccine.
COVID-19 vaccine. PHOTO BY GABRIEL BOUYS /AFP via Getty Images
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Scientists have pinpointed 16 new genetic variants in people who developed severe COVID-19 in a large study published on Monday that could help researchers develop treatments for very sick patients.
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The results suggest that people with severe COVID have genes that predispose them to one of two problems: failure to limit the ability of the virus to make copies of itself, or excessive inflammation and blood clotting.
The scientists said their discoveries, published in the journal Nature, could help prioritize the likely treatments that could work against the disease.
Eventually, the information could even help predict which patients were likely to become severely ill.
“It is potentially possible in future that we will be able to make predictions about patients based on their genome at the point of presenting (for) critical care,” said Kenneth Baillie, consultant in critical care medicine at the University of Edinburgh and one of the study authors, told reporters.
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The genetic analysis of nearly 56,000 samples from people in Britain showed differences in 23 genes in COVID-19 patients who became critically ill, when compared with the DNA of other groups included in the study, including 16 differences that had not been previously identified.
The new findings could help guide scientists in their search for existing drugs that might be useful for treating COVID-19.
For example, the researchers found changes in key genes that regulate the level of factor VIII, a protein involved in forming blood clots.
“Blood clotting is one of the main reasons why patients with COVID develop a shortage of oxygen. So that’s potentially targetable to prevent those clots from forming,” Baillie said.
But “we can’t know if these medicines will work until we try them in people.”
One of the previously discovered genes, TYK2, is targeted by Eli Lilly’s arthritis drug baricitinib, now being studied as a treatment for COVID-19.
The drug was shown last week to cut the risk of death and hospitalization in COVID-19 patients by 13% in a trial.
torontosun.com
Author of the article:Reuters
Reuters
Manas Mishra
Publishing date:Mar 07, 2022 • 15 hours ago • 1 minute read • 8 Comments
COVID-19 vaccine.
COVID-19 vaccine. PHOTO BY GABRIEL BOUYS /AFP via Getty Images
Article content
Scientists have pinpointed 16 new genetic variants in people who developed severe COVID-19 in a large study published on Monday that could help researchers develop treatments for very sick patients.
Advertisement
STORY CONTINUES BELOW
Article content
The results suggest that people with severe COVID have genes that predispose them to one of two problems: failure to limit the ability of the virus to make copies of itself, or excessive inflammation and blood clotting.
The scientists said their discoveries, published in the journal Nature, could help prioritize the likely treatments that could work against the disease.
Eventually, the information could even help predict which patients were likely to become severely ill.
“It is potentially possible in future that we will be able to make predictions about patients based on their genome at the point of presenting (for) critical care,” said Kenneth Baillie, consultant in critical care medicine at the University of Edinburgh and one of the study authors, told reporters.
Advertisement
STORY CONTINUES BELOW
Article content
The genetic analysis of nearly 56,000 samples from people in Britain showed differences in 23 genes in COVID-19 patients who became critically ill, when compared with the DNA of other groups included in the study, including 16 differences that had not been previously identified.
The new findings could help guide scientists in their search for existing drugs that might be useful for treating COVID-19.
For example, the researchers found changes in key genes that regulate the level of factor VIII, a protein involved in forming blood clots.
“Blood clotting is one of the main reasons why patients with COVID develop a shortage of oxygen. So that’s potentially targetable to prevent those clots from forming,” Baillie said.
But “we can’t know if these medicines will work until we try them in people.”
One of the previously discovered genes, TYK2, is targeted by Eli Lilly’s arthritis drug baricitinib, now being studied as a treatment for COVID-19.
The drug was shown last week to cut the risk of death and hospitalization in COVID-19 patients by 13% in a trial.
Scientists identify new gene differences in severe COVID patients
Scientists have pinpointed 16 new genetic variants in people who developed severe COVID-19 in a large study published on Monday that could help researchers develop …
Scientists identify new gene differences in severe COVID patients
Author of the article:Reuters
Reuters
Manas Mishra
Publishing date:Mar 07, 2022 • 15 hours ago • 1 minute read • 8 Comments
COVID-19 vaccine.
COVID-19 vaccine. PHOTO BY GABRIEL BOUYS /AFP via Getty Images
Article content
Scientists have pinpointed 16 new genetic variants in people who developed severe COVID-19 in a large study published on Monday that could help researchers develop treatments for very sick patients.
Advertisement
STORY CONTINUES BELOW
Article content
The results suggest that people with severe COVID have genes that predispose them to one of two problems: failure to limit the ability of the virus to make copies of itself, or excessive inflammation and blood clotting.
The scientists said their discoveries, published in the journal Nature, could help prioritize the likely treatments that could work against the disease.
Eventually, the information could even help predict which patients were likely to become severely ill.
“It is potentially possible in future that we will be able to make predictions about patients based on their genome at the point of presenting (for) critical care,” said Kenneth Baillie, consultant in critical care medicine at the University of Edinburgh and one of the study authors, told reporters.
Advertisement
STORY CONTINUES BELOW
Article content
The genetic analysis of nearly 56,000 samples from people in Britain showed differences in 23 genes in COVID-19 patients who became critically ill, when compared with the DNA of other groups included in the study, including 16 differences that had not been previously identified.
The new findings could help guide scientists in their search for existing drugs that might be useful for treating COVID-19.
For example, the researchers found changes in key genes that regulate the level of factor VIII, a protein involved in forming blood clots.
“Blood clotting is one of the main reasons why patients with COVID develop a shortage of oxygen. So that’s potentially targetable to prevent those clots from forming,” Baillie said.
But “we can’t know if these medicines will work until we try them in people.”
One of the previously discovered genes, TYK2, is targeted by Eli Lilly’s arthritis drug baricitinib, now being studied as a treatment for COVID-19.
The drug was shown last week to cut the risk of death and hospitalization in COVID-19 patients by 13% in a trial.
Scientists identify new gene differences in severe COVID patients
Scientists have pinpointed 16 new genetic variants in people who developed severe COVID-19 in a large study published on Monday that could help researchers develop …
And I'm sure there are a few on this board who will scream "Fake news!" or "Who cares" at this.
And of course those who will mutter darkly "They knew this all along. They withheld it so they could enslave us all with microchips! Only a handful of people needed the vaccine, if any at all!"
I warned about the "factor genes and blood proteins" right from day one as well as suggesting the preventative use of aspirin as a blood thinner after shots and during infection.
I guess you only read Twin Moose and B00Mers posts?
It's time for my daily doses...
Last edited:
Post in thread 'COVID-19 'Pandemic'' https://forums.canadiancontent.net/threads/covid-19-pandemic.167062/post-2888173
NB is on the 14th.
Part of the province is relieved, the rest of us are wondering if this will be a repeat of last year.
There is no guarantee they will stay off since a contract was signed by the Liberals for vaccine supply until 2024
Wonder why they don't put you in charge of Vague Warnings Canada.
The "contract" had nothing to do with NB going from no mandates to full blown lockdown in places last year. It had more to do with stupidity, ineptitude and the desire for $$ and clout vs. actual giving a shit about the province.
Because half of my bullshit isn't babbled en Francais?
Shall we review the past few post to see who is "paying attention"?
Where were you in 2020 when I first brought this up?
Last edited:
Autocorrupt decided is, I was going for isn't.
So. Did my warnings go unheeded or not?
You got Autocorrupt? See, you're all set to be the new head honcho at Vague Warnings Canada!
Six passengers fined over party flight from Montreal to Cancun
Images from the flight showed passengers not wearing masks, dancing in the aircraft’s aisles, vaping, drinking vodka from a full-sized bottle and taking selfies.
Author of the article:Montreal Gazette
Publishing date:Mar 08, 2022 • 15 hours ago • 2 minute read • 32 Comments
An investigation was prompted when media reports were circulating of passengers behaving inappropriately on a Sunwing Airlines flight from Montreal to Cancun, Mexico.
An investigation was prompted when media reports were circulating of passengers behaving inappropriately on a Sunwing Airlines flight from Montreal to Cancun, Mexico. INSTAGRAM
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Transport Canada says six people have been fined over a rowdy Montreal flight to Cancun, Mexico, that sparked international headlines and outrage after video emerged of passengers partying and appearing to flout public health rules.
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Images from the Dec. 30 Sunwing Airlines flight showed passengers not wearing face masks, ignoring social distancing rules and dancing in the aircraft’s aisles and passenger seats. Other images showed some passengers vaping, drinking vodka from a full-sized bottle and taking selfies.
In a statement published Tuesday, Transport Minister Omar Alghabra announced his department “has issued a series of penalties to passengers who were not fully vaccinated when they boarded their flight. To date, six passengers have received penalties, which could reach a maximum of $5,000 each.”
The investigation into “unacceptable behaviour” on the flight continues and more penalties are expected to be issued “in the coming days and weeks,” Alghabra said.
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The flight carried 154 passengers, some of whom were Quebec social media influencers and reality-show personalities.
Transport Canada has since Jan. 4 been conducting an investigation “to determine whether the Aeronautics Act, regulations or requirements pertaining to aviation safety and security were contravened during that flight,” the statement said.
“Certain behaviours reported in connection with the flight, are unacceptable and will not be tolerated,” Alghabra said. “This is why Transport Canada took immediate action. Aviation rules must be respected by everyone, for the sake of everyone’s safety. Transport Canada will continue to investigate and issue all necessary penalties.”
Under federal rules, all passengers must be fully vaccinated to board a flight departing from Canada.
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Passengers are also subject to all civil aviation regulations and requirements, Transport Canada said. A passenger can receive more than one penalty if they have contravened more than one rule.
After images of the flight went viral, Prime Minister Justin Trudeau called the passengers’ conduct irresponsible and a “slap in the face” to everyone who has been following public health restrictions. He referred to the passengers as “idiots” and “barbarians.”
“Like all Canadians who’ve seen the videos, I’m extremely frustrated,” Trudeau said.
In January, James William Awad, the organizer of the flight, said he was considering suing Sunwing Airlines for “breach of contract” after it refused to fly his group home.
MORE ON THIS TOPIC
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Sunwing party organizer fined for driving across Quebec border on last day of curfew
Transport Canada says passengers who violated the regulations could face fines of up to $5,000 per offence.
Trudeau says Sunwing party flight to Mexico 'a slap in the face'
Airlines won't fly home Quebec passengers from Sunwing party flight to Mexico
All our coronavirus-related news can be found at montrealgazette.com/tag/coronavirus.
For information on vaccines in Quebec, tap here.
Sign up for our email newsletter dedicated to local COVID-19 coverage at montrealgazette.com/coronavirusnews.
Help support our local journalism by subscribing to the Montreal Gazette.
canada.ca
torontosun.com
Images from the flight showed passengers not wearing masks, dancing in the aircraft’s aisles, vaping, drinking vodka from a full-sized bottle and taking selfies.
Author of the article:Montreal Gazette
Publishing date:Mar 08, 2022 • 15 hours ago • 2 minute read • 32 Comments
An investigation was prompted when media reports were circulating of passengers behaving inappropriately on a Sunwing Airlines flight from Montreal to Cancun, Mexico.
An investigation was prompted when media reports were circulating of passengers behaving inappropriately on a Sunwing Airlines flight from Montreal to Cancun, Mexico. INSTAGRAM
Article content
Transport Canada says six people have been fined over a rowdy Montreal flight to Cancun, Mexico, that sparked international headlines and outrage after video emerged of passengers partying and appearing to flout public health rules.
Advertisement 2
STORY CONTINUES BELOW
Article content
Images from the Dec. 30 Sunwing Airlines flight showed passengers not wearing face masks, ignoring social distancing rules and dancing in the aircraft’s aisles and passenger seats. Other images showed some passengers vaping, drinking vodka from a full-sized bottle and taking selfies.
In a statement published Tuesday, Transport Minister Omar Alghabra announced his department “has issued a series of penalties to passengers who were not fully vaccinated when they boarded their flight. To date, six passengers have received penalties, which could reach a maximum of $5,000 each.”
The investigation into “unacceptable behaviour” on the flight continues and more penalties are expected to be issued “in the coming days and weeks,” Alghabra said.
Advertisement 3
STORY CONTINUES BELOW
Article content
The flight carried 154 passengers, some of whom were Quebec social media influencers and reality-show personalities.
Transport Canada has since Jan. 4 been conducting an investigation “to determine whether the Aeronautics Act, regulations or requirements pertaining to aviation safety and security were contravened during that flight,” the statement said.
“Certain behaviours reported in connection with the flight, are unacceptable and will not be tolerated,” Alghabra said. “This is why Transport Canada took immediate action. Aviation rules must be respected by everyone, for the sake of everyone’s safety. Transport Canada will continue to investigate and issue all necessary penalties.”
Under federal rules, all passengers must be fully vaccinated to board a flight departing from Canada.
Advertisement 4
STORY CONTINUES BELOW
Article content
Passengers are also subject to all civil aviation regulations and requirements, Transport Canada said. A passenger can receive more than one penalty if they have contravened more than one rule.
After images of the flight went viral, Prime Minister Justin Trudeau called the passengers’ conduct irresponsible and a “slap in the face” to everyone who has been following public health restrictions. He referred to the passengers as “idiots” and “barbarians.”
“Like all Canadians who’ve seen the videos, I’m extremely frustrated,” Trudeau said.
In January, James William Awad, the organizer of the flight, said he was considering suing Sunwing Airlines for “breach of contract” after it refused to fly his group home.
None
Sunwing party organizer fined for driving across Quebec border on last day of curfew
Transport Canada says passengers who violated the regulations could face fines of up to $5,000 per offence.
Trudeau says Sunwing party flight to Mexico 'a slap in the face'
Airlines won't fly home Quebec passengers from Sunwing party flight to Mexico
All our coronavirus-related news can be found at montrealgazette.com/tag/coronavirus.
For information on vaccines in Quebec, tap here.
Sign up for our email newsletter dedicated to local COVID-19 coverage at montrealgazette.com/coronavirusnews.
Help support our local journalism by subscribing to the Montreal Gazette.
Transport Canada issues an initial series of penalties as part of its investigation into the Montréal–Cancun flight of December 30, 2021
In response to allegations of unacceptable behaviour reported to Transport Canada involving a flight from Montréal to Cancun on December 30, 2021, the department quickly launched an investigation.
Six passengers fined over party flight from Montreal to Cancun
Images from the flight showed passengers not wearing masks, dancing in the aircraft’s aisles, vaping, drinking vodka from a full-sized bottle and taking selfies.
COVID-19 can cause brain shrinkage, memory loss: Study
Author of the article:Reuters
Reuters
Publishing date:Mar 08, 2022 • 16 hours ago • 1 minute read • Join the conversation
A patient suffering from Long COVID is examined in the post-coronavirus disease (COVID-19) clinic of Ichilov Hospital in Tel Aviv, Israel, February 21, 2022.
A patient suffering from Long COVID is examined in the post-coronavirus disease (COVID-19) clinic of Ichilov Hospital in Tel Aviv, Israel, February 21, 2022. PHOTO BY AMIR COHEN /REUTERS
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COVID-19 can cause the brain to shrink, reduce grey matter in the regions that control emotion and memory, and damage areas that control the sense of smell, an Oxford University study has found.
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The scientists said that the effects were even seen in people who had not been hospitalized with COVID, and whether the impact could be partially reversed or if they would persist in the long term needed further investigation.
“There is strong evidence for brain-related abnormalities in COVID-19,” the researchers said in their study, which was released on Monday.
Even in mild cases, participants in the research showed “a worsening of executive function” responsible for focus and organizing, and on an average brain sizes shrank between 0.2% and 2%.
The peer-reviewed study, published in the Nature journal, investigated brain changes in 785 participants aged 51–81 whose brains were scanned twice, including 401 people who caught COVID between their two scans. The second scan was done on average 141 days after the first scan.
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The study was conducted when the Alpha variant was dominant in Britain and is unlikely to include anyone infected with the Delta variant.
Studies have found some people who had COVID suffered from “brain fog” or mental cloudiness that included impairment to attention, concentration, speed of information processing and memory.
The researchers did not say if vaccination against COVID had any impact on the condition but the UK Health Security Agency said last month that a review of 15 studies found that vaccinated people were about half as likely to develop symptoms of long COVID compared with the unvaccinated.
torontosun.com
Author of the article:Reuters
Reuters
Publishing date:Mar 08, 2022 • 16 hours ago • 1 minute read • Join the conversation
A patient suffering from Long COVID is examined in the post-coronavirus disease (COVID-19) clinic of Ichilov Hospital in Tel Aviv, Israel, February 21, 2022.
A patient suffering from Long COVID is examined in the post-coronavirus disease (COVID-19) clinic of Ichilov Hospital in Tel Aviv, Israel, February 21, 2022. PHOTO BY AMIR COHEN /REUTERS
Article content
COVID-19 can cause the brain to shrink, reduce grey matter in the regions that control emotion and memory, and damage areas that control the sense of smell, an Oxford University study has found.
Advertisement 2
STORY CONTINUES BELOW
Article content
The scientists said that the effects were even seen in people who had not been hospitalized with COVID, and whether the impact could be partially reversed or if they would persist in the long term needed further investigation.
“There is strong evidence for brain-related abnormalities in COVID-19,” the researchers said in their study, which was released on Monday.
Even in mild cases, participants in the research showed “a worsening of executive function” responsible for focus and organizing, and on an average brain sizes shrank between 0.2% and 2%.
The peer-reviewed study, published in the Nature journal, investigated brain changes in 785 participants aged 51–81 whose brains were scanned twice, including 401 people who caught COVID between their two scans. The second scan was done on average 141 days after the first scan.
Advertisement 3
STORY CONTINUES BELOW
Article content
The study was conducted when the Alpha variant was dominant in Britain and is unlikely to include anyone infected with the Delta variant.
Studies have found some people who had COVID suffered from “brain fog” or mental cloudiness that included impairment to attention, concentration, speed of information processing and memory.
The researchers did not say if vaccination against COVID had any impact on the condition but the UK Health Security Agency said last month that a review of 15 studies found that vaccinated people were about half as likely to develop symptoms of long COVID compared with the unvaccinated.
COVID-19 can cause brain shrinkage, memory loss: Study
COVID-19 can cause the brain to shrink, reduce grey matter in the regions that control emotion and memory, and damage areas that control the sense of smell, an Oxfo…