You mean like the climate being such a wildcard that there is no way in hell a model can predict jack ****?
No, I mean if you have something like this:
(1,2), (1,4), (1,-2), (1,5), (1, 3), (1,1), (1,4)
Only with thousands more of the same, the independent variable is not responsible for the response of the dependent variable.
Yet you maintain it's there. Contrary to the laws which govern the scientific method.
Here's a prediction:
Continuously adding more carbon dioxide in the atmosphere means that the temperature of the troposphere will rise above land and above the oceans, the stratosphere will cool, the temperature in the surface waters of the oceans will rise, the oceans will store more heat, the atmosphere will hold more water vapour, glaciers will melt, sea ice will melt, the sea level will rise, and the oceans will acidify.
Hmm, all have come true. Can you make all of that happen with any other single factor? Nope.