Not if he runs on his record.
He can run on whatever he wants.
If you honestly believe that Newt friggin Gingrich, Santorum or Ron Paul have a chance, you're sorely mistaken. The vote for the Republican head is competitive because Republicans lost their identity when they got spanked last time around. But anyone of those competing with Obama will fail because they're still pandering to a specific segment of the conservative market.
Their safest bet is the fabian, fiscal conservative lead coupled with the evangelist vice president to keep the stupid voters.
If anyone other than Romney goes up against Obama, they are gonna get run over, regardless of what issues are at play.