There are things about the universe that we will never understand. I would think that in order to truly understand the all-powerful we would need to be all-powerful. In science or spirituality, there will always be things beyond our comprehension. Some religions believe that the gods themselves are trapped the same cycles of ignorance, death, happiness and suffering.
Personally, I like to think it's a lot like the relationship between me and my cat. As a human, I'm more intelligent than my cat. I understand the way the universe works better than she can. I have a certain power over her, I can manipulate her but I can't control her. Sometimes I observe her and wonder what the hell is going through her mind. I'll never understand how she thinks or how she sees the world. And while she's figured out some of my behaviour, she won't fully understand me. I assume from my perspective as a human, her interpretation of the world is less sophisticated than mine, but I still don't understand it either.
In a way, if there is some higher power or some more sophisticated intelligence, our understandings of the universe are like Venn diagrams. There is some overlap in our knowledge and some things beyond our capacity.