14th May 1796 - British physician Edward Jenner carries out the world's first widely known vaccination. He innoculated an 8-year-old boy, James Phipps, against smallpox. However, a Dorset farmer, Benjamin Jesty, had successfully inoculated his wife and two children during a smallpox epidemic in 1774, but it was not until Jenner's work some twenty years later that the procedure became widely understood
Around this time smallpox was greatly feared, as one in three of those who contracted the disease died, and those who survived were commonly badly disfigured. Voltaire, a few years later, recorded that 60% of people caught smallpox, with 20% of the population dying of it. Jenner died of a 2nd stroke in 1823.
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Edward Jenner FRS (May 17, 1749 – January 26, 1823) was an English country doctor who studied nature and his natural surroundings from childhood and practiced medicine in Berkeley, Gloucestershire, England. He is famous as the first doctor to introduce and study the smallpox vaccine.
Jenner trained in Sodbury, Gloucestershire as an apprentice to Dr. Ludlow for 8 years from the age of 13, then went up to London in 1770 to study under the surgeon John Hunter (a noted experimentalist, and later a fellow of the Royal Society[1]) and others at St George's Hospital. William Osler records that Jenner was a student to whom Hunter repeated William Harvey's advice, very famous in medical circles, "Don't think, try". Jenner therefore was early noticed by men famous for advancing the practice and institutions of medicine, and Hunter remained in correspondence with him over natural history and proposed him for the Royal Society. Returning to his native countryside, by 1773 he became a successful general practitioner and surgeon, practicing in purpose-built premises at Berkeley.
Jenner and others formed a medical society in Rodborough, Gloucestershire, meeting to read papers on medical subjects and dine together. Jenner contributed papers on angina pectoris, ophthalmia and valvular disease of the heart and commented on cowpox. He also belonged to a similar society which met in Alveston, near Bristol.[1]
He was elected Fellow of the Royal Society in 1788, following a careful study combining observation, experiment and dissection into a description of the previously misunderstood life of the cuckoo in the nest.
Smallpox
Around this time smallpox was greatly feared, as one in three of those who contracted the disease died, and those who survived were commonly badly disfigured. Voltaire, a few years later, recorded that 60% of people caught smallpox, with 20% of the population dying of it. A Dorset farmer, Benjamin Jesty, had successfully inoculated his wife and two children during a smallpox epidemic in 1774, but it was not until Jenner's work some twenty years later that the procedure became widely understood. Indeed it is generally believed that Jenner was unaware of Jesty's success and arrived at his conclusions independently.
Jenner's Initial Theory
In fact he thought the initial source of infection was a disease of horses, called "the grease", and that this was transferred to cows by farmworkers, transformed, and then manifested as cowpox. From that point on he was correct, the complication probably arose from coincidence.
Noting the common observation that milkmaids did not generally get smallpox, Jenner theorized that the pus in the blisters which milkmaids received from cowpox (a disease similar to smallpox, but much less virulent) protected the milkmaids from smallpox. He may have had the advantage of hearing stories of Benjamin Jesty and perhaps others deliberately arranging cowpox infection of their families and of a reduced risk in those families.
In May 1796, Jenner tested his theory by inoculating James Phipps, a young boy, with material from the cowpox blisters of the hand of Sarah Nelmes, a milkmaid who had caught cowpox from a cow called Blossom. Phipps was the 17th case described in Jenners first paper on vaccination.
Jenner inoculated Phipps with cowpox pus in both arms on one day. This produced a fever and some uneasiness but no great illness. Later, he injected Phipps with variolous material, which would have been the routine attempt to produce immunity at that time. No disease followed. Jenner reported that later the boy was again challenged with variolacious material and again showed no sign of infection.
He continued his research and reported it to the Royal Society who did not publish the initial report. After improvement and further work he published a report of 23 cases. Some of his conclusions were correct, and some erroneous - modern microbiological and microscopic methods would make this easier to repeat. The medical establishment, then as now, considered his findings for some time before accepting them. Eventually vaccination was accepted and in 1840 the British government banned variolation and provided vaccination free of charge.
Jenner's continuing work on vaccination prevented his continuing his ordinary medical practice. He was supported by his colleagues and the King in petitioning Parliament and was granted £10,000 for his work on vaccination. In 1806 he was granted another £20 000 for his continuing work.
In 1803 in London he became involved with the Jennerian Institution, a society concerned with promoting vaccination to eradicate smallpox. In 1808, with government aid, this society became the National Vaccine Establishment.
Jenner became a member of the Medical and Chirurgical Society on its foundation in 1805, and subsequently presented to them a number of papers. This is now the Royal Society of Medicine.
Returning to London in 1811 he observed a significant number of cases of smallpox after vaccination occurring. He found that in these cases the severity of the illness was notably diminished by the previous vaccination.
In 1813 the University of Oxford awarded him the degree of MD.
In 1821 he was appointed Physician Extraordinary to King George IV, a considerable national honour, and was made Mayor of Berkeley and Justice of the Peace.
He continued his interests in natural history and 1823 he presented "Observations on the Migration of Birds" to the Royal Society.
He died of his second stroke on 26 January 1823, having fully recovered from the first, and was survived by one son and one daughter, the eldest son having died of tuberculosis aged 21.
In 1980, the World Health Organisation declared smallpox an eradicated disease. This was the result of coordinated public health efforts by many people, but vaccination was an essential component.
Statue of Jenner in Kensington Gardens, London.
wikipedia.org
Also on this day -
1847 - HMS Driver completes the first circumnavigation of the world by a steamship when it arrives at Spithead on the Hampshire coast.
1921 - In the United States, Florence Allen becomes the first woman judge to sentence a man to death. Frank Motto is found guilty of murder and executed on August 20th.
1940 - Most of Rotterdam, Holland is destroyed by German bombing – killing 1,000 and making more than 50,000 homeless.