Depression is anger without enthusiasm. No drug or chemical concoction will be useful to everyone and may be harmful to some. There may be a chemical imbalance present during depression but not all depressions last. With a little understanding, depression can be avoided and/or relieved in a short time. Because of my severe head trauma I suffered from suicidal depressions for a long time, but when I researched the causes and triggers that set them off, I was able to stop my depressions at the outset without drugs (including alcohol - which BTW is a depressant and the high can easily become severe depression with just one more glass). Depression has become an industry with pharmaceuticals and psychiatry. Mental health is our responsibility not theirs. If you do not take responsibility for your own health, mental and physical, you become nothing more than a guiny pig for the Unhealth industry.