1. Same thing I do now. Ignore 'em.
2. If "You're a retarded asshole" comprises "calling it out" and "confronting it," I already do.
3. My best friend is a woman, so not an issue.
4. It's a moron mouthing off.
There's no shame in being disgusted by the disgusting.
Now I have a question for you. Are you an imbecile because of genetics, or have you just taken a lot of blows to the head?