edmontonsun.com
New research out of the University of Alberta shows that a gene found in the human body could be used to stop the spread of HIV.
"It's very exciting for patients who are infected with HIV," said researcher Dr. Stephen Barr.
"It gives them another target or hope that there is another gene that can help them out in their fight."
News that there could be another weapon against HIV/AIDS is indeed a big deal, said Debra Jakubec, executive director of HIV Edmonton.
"It's exciting research. It is still probably a far ways from getting it out of clinical research but it is exciting," added Jakubec.
Three years ago while at the University of Pennsylvania, Barr, 32, began his work on a gene called TRIM22 - work that continued when he moved to the University of Alberta's department of medical microbiology and immunology two years ago.
TRIM22 is a gene in humans that fights viruses. For a reason still unknown, TRIM22 doesn't work in patients with Human Immunodeficiency Virus (HIV).
But lab tests have shown that when TRIM22 is turned on in cell cultures infected with HIV, the gene stops the assembly of the virus and essentially locks the virus in the cell like a prisoner in a cage. If it can't get out of the cell, the spread of HIV is stopped in its tracks.
"This gene works particularly at preventing the virus from getting out of cells. So it can't stop the virus from getting in (to the cell) but it can lock it in so it can't get out," said Barr, whose research is being published in the medical journal PloS Pathogens.
It's not a cure, cautioned Barr. It hasn't been tried in live patients so it's not known if TRIM22 could be turned on in a person or what would happen, but it could be a major step towards finding a cure
Full article
New research out of the University of Alberta shows that a gene found in the human body could be used to stop the spread of HIV.
"It's very exciting for patients who are infected with HIV," said researcher Dr. Stephen Barr.
"It gives them another target or hope that there is another gene that can help them out in their fight."
News that there could be another weapon against HIV/AIDS is indeed a big deal, said Debra Jakubec, executive director of HIV Edmonton.
"It's exciting research. It is still probably a far ways from getting it out of clinical research but it is exciting," added Jakubec.
Three years ago while at the University of Pennsylvania, Barr, 32, began his work on a gene called TRIM22 - work that continued when he moved to the University of Alberta's department of medical microbiology and immunology two years ago.
TRIM22 is a gene in humans that fights viruses. For a reason still unknown, TRIM22 doesn't work in patients with Human Immunodeficiency Virus (HIV).
But lab tests have shown that when TRIM22 is turned on in cell cultures infected with HIV, the gene stops the assembly of the virus and essentially locks the virus in the cell like a prisoner in a cage. If it can't get out of the cell, the spread of HIV is stopped in its tracks.
"This gene works particularly at preventing the virus from getting out of cells. So it can't stop the virus from getting in (to the cell) but it can lock it in so it can't get out," said Barr, whose research is being published in the medical journal PloS Pathogens.
It's not a cure, cautioned Barr. It hasn't been tried in live patients so it's not known if TRIM22 could be turned on in a person or what would happen, but it could be a major step towards finding a cure
Full article