"If it could be demonstrated that any complex organ existed which could not possibly have been formed by numerous, successive, slight modifications, my theory would absolutely break down"
Charles Darwin, "The Origin of the Species"
"We should reject, as a matter of principle, the substitution of intelligent design for the dialogue of chance and necessity; but we must concede that there are presently no detailed Darwinian accounts of the evolution of any biochemical system, only a variety of wishful speculations.
Biochemist Franklin M. Harold, "The Way of the Cell" (Oxford University Press, 2001) 205
"We have always underestimated the cell....The entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each of which is composed of a set of large protein machines... Why do we call [them] machines? Precisely because, like machines invented by humans to deal efficiently with the macroscopic world, these protein assemblies contain highly coordinated moving parts.
Bruce Alberts, President, National Academy of Sciences, "The Cell as a Collection of Protein Machines" Cell 92 (Feb. 8, 1998)
Explain how a cell could have evolved by numerous, successive, slight modifications.