This forces us to the conclusion that causality in cells is exercised downwardly from the phenotype to the genotype (for example, to initiate transcription or even modify the genomic sequence), exactly the reverse of the Genotype to Phenotype (G -> P) concept underpinning population genetics.
A Challenge to the Supremacy of DNA as the Genetic Material - DNA Science Blog
A Challenge to the Supremacy of DNA as the Genetic Material - DNA Science Blog