Hawkings former plumber
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October 17th, 2007, 11:56 AM
FDA Regulation “Hurts” for Depression Drug Maker Eli Lilly
by Martha Rosenberg / October 17th, 2007
It was supposed to replace Prozac profits when the patent expired in 2001 and cash in on the national love affair with antidepressants.
But Eli Lilly & Co.’s Cymbalta (duloxetine) seemed cursed from the start.
The first antidepressant to be introduced since FDA investigations into suicide/antidepressant links, Cymbalta itself was marred with suicides before it was approved.
Five occurred during Cymbalta clinical trials including previously healthy volunteer Traci Johnson who hung herself in Lilly’s Indiana University Medical School lab in 2004.
“Their posturing was offensive,” said the Rev. Joel Barnaby, spokesman for Traci Johnson’s family upon hearing Lilly would not delay the drug’s planned introduction. “They were saying that this little death certainly should not defame our study or, God forbid, make us miss a deadline for FDA approval.”
Nor was Traci, “in a depressed state of mind or had a spirit wounded so much that she gave up on life,” Mr. Barnaby said.
Despite $208 million in sales in its first eight months of marketing thanks to auto suggestive “Depression Hurts” television ads and do-you-have-this-disease? symptom checklists on its web site, Cymbalta’s bad buzz didn’t go away.
A year after Cymbalta hit drug store shelves it was indicted for causing more than twice the rate of suicide attempts in women prescribed the drug for stress urinary incontinence–a use not approved in the US–according to the FDA.
Last May, the FDA ordered Lilly to add a black box to Cymbalta warning about suicides and antidepressants in young adults.
And in October Lilly was told to “immediately cease” its Cymbalta campaign for diabetic nerve pain–an approved use–which promises “significantly less pain interference with overall functioning.” In a letter, the FDA says the claim “has not been demonstrated by substantial evidence or … clinical experience” nor do the Cymbalta marketing pieces give precautions about liver toxicity or reveal risks for patients with certain conditions.
(Lilly spokesman Charlie McAtee said Lilly will take action once it has “more clarity” on FDA objections. Which part of “immediately cease” does he not understand?)
Even Lilly’s own reps are trashing the drug on the pharma chat room cafepharma.com.
“My territory includes a high percent of blue collar beer guzzlers that drive home from work with a six pack on their lap,” wrote one anonymous poster. “The Docs around here won’t touch Cymbalta.”
“This prohttp://www.dissidentvoice.org
FDA Regulation “Hurts” for Depression Drug Maker Eli Lilly
by Martha Rosenberg / October 17th, 2007
It was supposed to replace Prozac profits when the patent expired in 2001 and cash in on the national love affair with antidepressants.
But Eli Lilly & Co.’s Cymbalta (duloxetine) seemed cursed from the start.
The first antidepressant to be introduced since FDA investigations into suicide/antidepressant links, Cymbalta itself was marred with suicides before it was approved.
Five occurred during Cymbalta clinical trials including previously healthy volunteer Traci Johnson who hung herself in Lilly’s Indiana University Medical School lab in 2004.
“Their posturing was offensive,” said the Rev. Joel Barnaby, spokesman for Traci Johnson’s family upon hearing Lilly would not delay the drug’s planned introduction. “They were saying that this little death certainly should not defame our study or, God forbid, make us miss a deadline for FDA approval.”
Nor was Traci, “in a depressed state of mind or had a spirit wounded so much that she gave up on life,” Mr. Barnaby said.
Despite $208 million in sales in its first eight months of marketing thanks to auto suggestive “Depression Hurts” television ads and do-you-have-this-disease? symptom checklists on its web site, Cymbalta’s bad buzz didn’t go away.
A year after Cymbalta hit drug store shelves it was indicted for causing more than twice the rate of suicide attempts in women prescribed the drug for stress urinary incontinence–a use not approved in the US–according to the FDA.
Last May, the FDA ordered Lilly to add a black box to Cymbalta warning about suicides and antidepressants in young adults.
And in October Lilly was told to “immediately cease” its Cymbalta campaign for diabetic nerve pain–an approved use–which promises “significantly less pain interference with overall functioning.” In a letter, the FDA says the claim “has not been demonstrated by substantial evidence or … clinical experience” nor do the Cymbalta marketing pieces give precautions about liver toxicity or reveal risks for patients with certain conditions.
(Lilly spokesman Charlie McAtee said Lilly will take action once it has “more clarity” on FDA objections. Which part of “immediately cease” does he not understand?)
Even Lilly’s own reps are trashing the drug on the pharma chat room cafepharma.com.
“My territory includes a high percent of blue collar beer guzzlers that drive home from work with a six pack on their lap,” wrote one anonymous poster. “The Docs around here won’t touch Cymbalta.”
“This prohttp://www.dissidentvoice.org
Time Out
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October 17th, 2007, 12:04 PM
Ok i took the cholesteral drug lipator....by the way almonds and walnuts work much better.....anyway after a few months of it all i wanted to do was off myself....i could thinkof nothing else and it made more sense to me than ever before...(lols at the thought of certain members pleading with me to start it again)...anyway went to family doctor refused to listen....therapist told me to stop it....it went away ...family doctor next to begged me to get back on it and within 3 weeks it all came back.....stopped it.....few years later it broke the news that a certain percentage of people will expierence a (psychotic?) depressive suicidal expierence from this stuff...
it's weird to watch a drug do this to you..i have so much expierence with me head that i've learned a skill to ignore certain episodes...lol
Ok i took the cholesteral drug lipator....by the way almonds and walnuts work much better.....anyway after a few months of it all i wanted to do was off myself....i could thinkof nothing else and it made more sense to me than ever before...(lols at the thought of certain members pleading with me to start it again)...anyway went to family doctor refused to listen....therapist told me to stop it....it went away ...family doctor next to begged me to get back on it and within 3 weeks it all came back.....stopped it.....few years later it broke the news that a certain percentage of people will expierence a (psychotic?) depressive suicidal expierence from this stuff...
it's weird to watch a drug do this to you..i have so much expierence with me head that i've learned a skill to ignore certain episodes...lol
October 17th, 2007, 12:21 PM
I was put on Paxil in an attempt to ease pain transmission.
I argued and argued that I didn't want to be on an anti-depressant as I wasn't depressed. But, the docs wouldn't listen, and refused to talk to me about my pain any further, or even refer me to a specialist, until I started on their anti-depressants. By the time I started, the docs (GP's, not shrinks btw) had told me so many times that I must have underlying depression, that I was starting to believe them. So, onto Paxil I went.
Its progress was so slow that I didn't even realize anything was wrong, until the day I woke up happy for the first time in two months. Happy, because I'd realized that if I was to just gas myself in my van, I could sleep all I wanted. My constant exhaustion would be gone. I had it all planned out, and was on my way to the store, when I realized I probably shouldn't bring my kids along. And if I shouldn't bring my kids along, then I'd better plan to have hubby watch them. And then... oh crap... who's going to watch them when he goes to work? Thank goodness I snapped out of it enough to realize something had gone screwy. I went through three weeks of puking, gut wrenching withdrawal, and got my life back together.
To this day, I've only ever had ONE doc acknowledge that it was the medication. Every other doctor who's suggested them as a pain measure tells me it wasn't the drugs making me suicidal, it was a failure of the drugs to prevent suicidal thought that was the issue... despite me never having been suicidal before.
I tell my story here often, I know. Many of you have probably read it before. But I tell it to anyone who will listen, anyone who might take something like this without adequate counseling and support from a psychiatrist. No GP should be handing these sorts of meds out as an experiment.
I was put on Paxil in an attempt to ease pain transmission.
I argued and argued that I didn't want to be on an anti-depressant as I wasn't depressed. But, the docs wouldn't listen, and refused to talk to me about my pain any further, or even refer me to a specialist, until I started on their anti-depressants. By the time I started, the docs (GP's, not shrinks btw) had told me so many times that I must have underlying depression, that I was starting to believe them. So, onto Paxil I went.
Its progress was so slow that I didn't even realize anything was wrong, until the day I woke up happy for the first time in two months. Happy, because I'd realized that if I was to just gas myself in my van, I could sleep all I wanted. My constant exhaustion would be gone. I had it all planned out, and was on my way to the store, when I realized I probably shouldn't bring my kids along. And if I shouldn't bring my kids along, then I'd better plan to have hubby watch them. And then... oh crap... who's going to watch them when he goes to work? Thank goodness I snapped out of it enough to realize something had gone screwy. I went through three weeks of puking, gut wrenching withdrawal, and got my life back together.
To this day, I've only ever had ONE doc acknowledge that it was the medication. Every other doctor who's suggested them as a pain measure tells me it wasn't the drugs making me suicidal, it was a failure of the drugs to prevent suicidal thought that was the issue... despite me never having been suicidal before.
I tell my story here often, I know. Many of you have probably read it before. But I tell it to anyone who will listen, anyone who might take something like this without adequate counseling and support from a psychiatrist. No GP should be handing these sorts of meds out as an experiment.
Time Out
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October 17th, 2007, 12:33 PM
First time I read it Karrie love.....Thanks ....
It is wierd though how the mind can direct you to such a thing....To survive what you just described says a lot about your person....Only those that have exopierenced that know the level of detacthment and finding a refuge in amongst the mind set....and it is a mind set...not some horror movie voices in your head.......
Knowing this why do they continue to ....Hell they want sandy on antidepressants to combat fibro pain as well..We won't have it....
I get so pissed at doctors....
First time I read it Karrie love.....Thanks ....
It is wierd though how the mind can direct you to such a thing....To survive what you just described says a lot about your person....Only those that have exopierenced that know the level of detacthment and finding a refuge in amongst the mind set....and it is a mind set...not some horror movie voices in your head.......
Knowing this why do they continue to ....Hell they want sandy on antidepressants to combat fibro pain as well..We won't have it....
I get so pissed at doctors....
Hawkings former plumber
Posts: 8,444
Videos: 1
Location: RR1 Distopia 666 Discordia Drive Apt 911
Videos: 1
Location: RR1 Distopia 666 Discordia Drive Apt 911
October 17th, 2007, 12:39 PM
General Practicioners should not be prescribing medication, they know relativly little about drugs and combinations or side effects. The most likely cause of anyones drug death or illness will be your own doctor, globally they sentence many patient to death or a life of pain and anquish.
It's been almost twenty years since I was diagnosed with degenerative arthritis if I had not noticed immeadiately that the prescribed medicines (non steroidal anti-inflamatories) didn't like me I would most likely be dead from them. Also when the drug has killed the pain , if indeed it does, then I'm inclined to work till it hurts again which is defeating the purpose. Pain needs a cure or it needs careful managing and this is very difficult to build when the stuff that relieves or cures is illegle. And it's illegle so that thieving pricks can sell thier deadly crap.
General Practicioners should not be prescribing medication, they know relativly little about drugs and combinations or side effects. The most likely cause of anyones drug death or illness will be your own doctor, globally they sentence many patient to death or a life of pain and anquish.
It's been almost twenty years since I was diagnosed with degenerative arthritis if I had not noticed immeadiately that the prescribed medicines (non steroidal anti-inflamatories) didn't like me I would most likely be dead from them. Also when the drug has killed the pain , if indeed it does, then I'm inclined to work till it hurts again which is defeating the purpose. Pain needs a cure or it needs careful managing and this is very difficult to build when the stuff that relieves or cures is illegle. And it's illegle so that thieving pricks can sell thier deadly crap.
October 17th, 2007, 12:39 PM
Doc... I'd never say she should or shouldn't try an anti-d based on my experience.
BUT... if she does decide to give it a try, she should be paying close attention, and having someone else pay close attention too. Just knowing (which I didn't at the time), can be the key.
Doc... I'd never say she should or shouldn't try an anti-d based on my experience.
BUT... if she does decide to give it a try, she should be paying close attention, and having someone else pay close attention too. Just knowing (which I didn't at the time), can be the key.
Quoting DocDred
First time I read it Karrie love.....Thanks ....
It is wierd though how the mind can direct you to such a thing....To survive what you just described says a lot about your person....Only those that have exopierenced that know the level of detacthment and finding a refuge in amongst the mind set....and it is a mind set...not some horror movie voices in your head.......
Knowing this why do they continue to ....Hell they want sandy on antidepressants to combat fibro pain as well..We won't have it....
I get so pissed at doctors....
It is wierd though how the mind can direct you to such a thing....To survive what you just described says a lot about your person....Only those that have exopierenced that know the level of detacthment and finding a refuge in amongst the mind set....and it is a mind set...not some horror movie voices in your head.......
Knowing this why do they continue to ....Hell they want sandy on antidepressants to combat fibro pain as well..We won't have it....
I get so pissed at doctors....
Hawkings former plumber
Posts: 8,444
Videos: 1
Location: RR1 Distopia 666 Discordia Drive Apt 911
Videos: 1
Location: RR1 Distopia 666 Discordia Drive Apt 911
October 17th, 2007, 12:40 PM
General Practicioners should not be prescribing medication, they know relativly little about drugs and combinations or side effects. The most likely cause of anyones drug death or illness will be your own doctor, globally they sentence many patients to death or a life of pain and anquish or addiction.
It's been almost twenty years since I was diagnosed with degenerative arthritis if I had not noticed immeadiately that the prescribed medicines (non steroidal anti-inflamatories) didn't like me I would most likely be dead from them. Also when the drug has killed the pain , if indeed it does, then I'm inclined to work till it hurts again which is defeating the purpose. Pain needs a cure or it needs careful managing and this is very difficult to build when the stuff that relieves or cures is illegle. And it's illegle so that thieving pricks can sell thier deadly crap.
General Practicioners should not be prescribing medication, they know relativly little about drugs and combinations or side effects. The most likely cause of anyones drug death or illness will be your own doctor, globally they sentence many patients to death or a life of pain and anquish or addiction.
It's been almost twenty years since I was diagnosed with degenerative arthritis if I had not noticed immeadiately that the prescribed medicines (non steroidal anti-inflamatories) didn't like me I would most likely be dead from them. Also when the drug has killed the pain , if indeed it does, then I'm inclined to work till it hurts again which is defeating the purpose. Pain needs a cure or it needs careful managing and this is very difficult to build when the stuff that relieves or cures is illegle. And it's illegle so that thieving pricks can sell thier deadly crap.
October 17th, 2007, 12:44 PM
NSAIDS are horrible. The only NSAID I take is the occasional dose of Mersyndol. and very occasional. Too often, and you're back in the doc's office, needing a new scrip for the ulcer. Yay.
I actually went to a doc here about 2 months ago, with wide spread neuralgia in my neck and back, right under the skin. It had been eating at me for weeks, and not going away. He asked if I was on any meds... no... asked why, and I explained my ulcers. So, he says "well, there's a new NSAID out that's easier on your stomach." Great!
He gives me a sample, and out of habit (because docs have tried to kill me with samples before), I headed to the nearest pharmacy to ask about it. The pharmacist said "yeah, it's a basic NSAID... just be sure to eat when you take it... it's really bad for causing ulcers."
freaking docs. (no offense Doc)
NSAIDS are horrible. The only NSAID I take is the occasional dose of Mersyndol. and very occasional. Too often, and you're back in the doc's office, needing a new scrip for the ulcer. Yay.
I actually went to a doc here about 2 months ago, with wide spread neuralgia in my neck and back, right under the skin. It had been eating at me for weeks, and not going away. He asked if I was on any meds... no... asked why, and I explained my ulcers. So, he says "well, there's a new NSAID out that's easier on your stomach." Great!
He gives me a sample, and out of habit (because docs have tried to kill me with samples before), I headed to the nearest pharmacy to ask about it. The pharmacist said "yeah, it's a basic NSAID... just be sure to eat when you take it... it's really bad for causing ulcers."
freaking docs. (no offense Doc)
