On January 28, 1996, he suffered a severe stroke, which impaired his ability to speak. Doctors told his wife that unless there was rapid improvement, the loss of the ability to speak was likely permanent. After a regime of daily speech-language therapy that lasted several months, his ability to speak returned, although it was still limited. He was able to accept an honorary Academy Award two months later in March and thanked the audience. He wrote about this experience in his 2002 book, My Stroke of Luck, which he hoped would be an "operating manual" for others on how to handle a stroke victim in their own family.
On December 9, 2016, Douglas became a centenarian. He celebrated his 100th birthday at the Beverly Hills Hotel, joined by several of his friends and family, including Don Rickles, Jeffrey Katzenberg, Steven Spielberg, his wife Anne, his son Michael and his daughter-in-law Catherine Zeta-Jones. Douglas was described by his guests as being still in good shape, able to walk with confidence into the Sunset Room for the celebration.
Douglas died at his home in Beverly Hills, California, on February 5, 2020, at age 103 from natural causes.