WASHINGTON -- Add another risk to hormone therapy after menopause: Benign breast lumps. One type of hormone therapy -- estrogen plus progestin -- already is well-known to increase the risk of breast cancer. But a major study of women able to use estrogen alone didn't find that link.Quote has been trimmed
Tuesday, researchers reported a new wrinkle: Those estrogen-only users doubled their chances of getting non-cancerous breast lumps. That's a concern not only because of the extra biopsies and worry those lumps cause, but because a particular type -- called benign proliferative breast disease -- is suspected of being a first step toward developing cancer 10 years or so later.
About one in five women undergo a breast biopsy within a decade of starting annual mammograms, and most are of those abnormalities turn out to be benign. Yet under a microscope, there are different types, from simple fluid-filled cysts to what's called proliferative breast disease because it's made of growing cells.
The latest work, published in the Journal of the National Cancer Institute, re-examines data from the landmark Women's Health Initiative that found a variety of health risks from long-term hormone therapy.
Only women who have undergone hysterectomies are able to use estrogen-only therapy, and the WHI originally included more than 10,000 of those women, who were given either estrogen or a dummy drug and tracked for about seven...