According to the station's official Facebook fan page, which is sponsored by Naval Station Norfolk, the incident occurred at approximately 11:20 p.m. at Pier 1.
Terri Davis, a base spokeswoman, told The Associated Press that the two men who died were a sailor and a civilian.
No other injuries were reported.
U.S. Navy security forces responded to the shooting and placed the station in lockdown as a precaution. The lockdown was later lifted.
At the time of this writing, no other details have been released.
Naval Station Norfolk is the world's largest naval station, Military.com reports. The station supports at least 75 ships and 134 aircraft.
Naval Station Norfolk Shooting Leaves 2 Dead (VIDEO)