At the moment, Frisky Dingo.
Home movies was great!
The Simpsons and Futurerama along with Family Guy and American Dad are always good to pass the time or eat dinner to. Never fail to get a laugh out of me.
Afro Samurai is excellent though it takes a little bit of effort to get into. Worth it though. The movie is really good.
Morel Orel has a style to the humour that is killer, but it doesn't catch you like some of the others. Still really funny though.
Squid Billys was pretty good too but it seemed to fail in the writing before long.
Robot Chicken is probably the king of late night toonage as it has a broader appeal, though I don't know if it hit the funny bone as hard as some of the others. I think there is perhaps a tie to the Family Guy franchise in the way that it's marketed.
There are others that have merit, Space Ghost, Sealab, Metalocracy(?) that could be bigger than they are.